NBA 2K21 is a Sports, Basketball, Single-player and Multiplayer video game developed by Visual Concepts for several platforms. It serves as the twenty-second installment in the series of NBA 2K and offers similar gameplay with the latest features. During the gameplay, the player acts like a basketball athlete, where he must follow the rules and regulations of NBA adventure.

The game offers the top thirty-six best teams for every playable mode. More than 200 basketball clubs, four announcers, and two analyzers are available to play. Up to three modes, such as MyCareer, MyLeague, and MyTeam, lets the player experience new gameplay. MyCareer is a career mode in which the player creates his basketball character and plays through a basketball career. The player can get haircuts, tattoos, and purchase boosts for the character.

MyTeam mode offers the player to play with his team in a tournament to compete with other teams. In contrast, multiplayer mode lets the player can invite other players to join his team. The victories award virtual currency that the player can use to unlock a variety of assets.